https://www.worlddoctorsalliance.com/tags/the-lancet/ Recent content in The Lancet on World Doctors Alliance Hugo -- gohugo.io en Wed, 23 Dec 2020 19:06:14 +0000 https://www.worlddoctorsalliance.com/blog/use-of-adenovirus-type5-vectored-vaccines-a-cautionarytale/ Wed, 23 Dec 2020 19:06:14 +0000 https://www.worlddoctorsalliance.com/blog/use-of-adenovirus-type5-vectored-vaccines-a-cautionarytale/ We are writing to express concern about the use of a recombinant adenovirus type-5 (Ad5) vector for a COVID-19 phase 1 vaccine study,1 and subsequent advanced trials. Over a decade ago, we completed the Step and Phambili phase 2b studies that evaluated an Ad5 vectored HIV-1 vaccine administered in three immunisations for efficacy against HIV-1 acquisition.2,3 Both international studies found an increased risk of HIV-1 acquisition among vaccinated men.2, 4